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KMID : 1200020200440050726
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Diabetes & Metabolism Journal
2020 Volume.44 No. 5 p.726 ~ p.736
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A Comparison of Predictive Performances between Old versus New Criteria in a Risk-Based Screening Strategy for Gestational Diabetes Mellitus
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Hong Su-Been
Lee Seung-Mi
Kwak Soo-Heon
Kim Byoung-Jae
Koo Ja-Nam
Oh Ig-Hwan
Oh So-Hee
Kim Sun-Min
Shin Sue
Kim Won
Joo Sae-Kyung
Norwitz Errol R.
Louangsenlath Souphaphone
Park Chan-Wook
Jun Jong-Kwan
Park Joong-Shin
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Abstract
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Background: The definition of the high-risk group for gestational diabetes mellitus (GDM) defined by the American College of Obstetricians and Gynecologists was changed from the criteria composed of five historic/demographic factors (old criteria) to the criteria consisting of 11 factors (new criteria) in 2017. To compare the predictive performances between these two sets of criteria.
Methods: This is a secondary analysis of a large prospective cohort study of non-diabetic Korean women with singleton pregnancies designed to examine the risk of GDM in women with nonalcoholic fatty liver disease. Maternal fasting blood was taken at 10 to 14 weeks of gestation and measured for glucose and lipid parameters. GDM was diagnosed by the two-step approach.
Results: Among 820 women, 42 (5.1%) were diagnosed with GDM. Using the old criteria, 29.8% (n=244) of women would have been identified as high risk versus 16.0% (n=131) using the new criteria. Of the 42 women who developed GDM, 45.2% (n=19) would have been mislabeled as not high risk by the old criteria versus 50.0% (n=21) using the new criteria (1-sensitivity, 45.2% vs. 50.0%, P>0.05). Among the 778 patients who did not develop GDM, 28.4% (n=221) would have been identified as high risk using the old criteria versus 14.1% (n=110) using the new criteria (1-specificity, 28.4% vs. 14.1%, P<0.001).
Conclusion: Compared with the old criteria, use of the new criteria would have decreased the number of patients identified as high risk and thus requiring early GDM screening by half (from 244 [29.8%] to 131 [16.0%]).
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KEYWORD
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Diabetes, gestational, Diagnostic screening programs, Pregnancy, high-risk
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